Microscopic observations of needle and soft-tissue simulant interactions

Currently, physicians have no means of correctly estimating the needle tip location during percutaneous needle insertion. A model of needle-tissue interaction that predicts the needle tip location would assist physicians in pre-operative planning and hence improve needle targeting accuracy. This study is aimed to investigate the interactions of bevel-tipped needles and soft tissue in situ, using agarose gel as a soft-tissue simulant. An experimental setup is designed to record the needle-gel interaction forces and torques during needle insertion. Gel rupture during needle insertion is observed using a Laser Scanning Confocal Microscope and recorded in time series and three-dimensional images (Figure). Experimental results show the possibility of observing in situ gel rupture during needle insertion and relating them to the needle-gel interaction forces and torques. Moreover, it is seen that the maximum force along the insertion axis, |Fz max|, is proportional to bevel angle and inversely proportional to insertion speed. The maximum resultant torque, ||Tr max||, is found to be inversely proportional to bevel angle and proportional to insertion speed. However, the influence of the increase in insertion speed in |Fz max| and ||Tr max|| diminishes as insertion speed increases. These results concur with observations noted in gel rupture images

Realistic tool-tissue interaction models for surgical simulation and planning

Surgical simulators present a safe and potentially effective method for surgical training, and can also be used in pre- and intra-operative surgical planning. Realistic modeling of medical interventions involving tool-tissue interactions has been considered to be a key requirement in the development of high-fidelity simulators and planners. The soft-tissue constitutive laws, organ geometry and boundary conditions imposed by the connective tissues surrounding the organ, and the shape of the surgical tool interacting with the organ are some of the factors that govern the accuracy of medical intervention planning.\ud \ud This thesis is divided into three parts. First, we compare the accuracy of linear and nonlinear constitutive laws for tissue. An important consequence of nonlinear models is the Poynting effect, in which shearing of tissue results in normal force; this effect is not seen in a linear elastic model. The magnitude of the normal force for myocardial tissue is shown to be larger than the human contact force discrimination threshold. Further, in order to investigate and quantify the role of the Poynting effect on material discrimination, we perform a multidimensional scaling study. Second, we consider the effects of organ geometry and boundary constraints in needle path planning. Using medical images and tissue mechanical properties, we develop a model of the prostate and surrounding organs. We show that, for needle procedures such as biopsy or brachytherapy, organ geometry and boundary constraints have more impact on target motion than tissue material parameters. Finally, we investigate the effects surgical tool shape on the accuracy of medical intervention planning. We consider the specific case of robotic needle steering, in which asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. We present an analytical and finite element (FE) model for the loads developed at the bevel tip during needle-tissue interaction. The analytical model explains trends observed in the experiments. We incorporated physical parameters (rupture toughness and nonlinear material elasticity) into the FE model that included both contact and cohesive zone models to simulate tissue cleavage. The model shows that the tip forces are sensitive to the rupture toughness. In order to model the mechanics of deflection of the needle, we use an energy-based formulation that incorporates tissue-specific parameters such as rupture toughness, nonlinear material elasticity, and interaction stiffness, and needle geometric and material properties. Simulation results follow similar trends (deflection and radius of curvature) to those observed in macroscopic experimental studies of a robot-driven needle interacting with gels

Image-Based Flexible Endoscope Steering

Manually steering the tip of a flexible endoscope to navigate through an endoluminal path relies on the physician’s dexterity and experience. In this paper we present the realization of a robotic flexible endoscope steering system that uses the endoscopic images to control the tip orientation towards the direction of the lumen. Two image-based control algorithms are investigated, one is based on the optical flow and the other is based on the image intensity. Both are evaluated using simulations in which the endoscope was steered through the lumen. The RMS distance to the lumen center was less than 25% of the lumen width. An experimental setup was built using a standard flexible endoscope, and the image-based control algorithms were used to actuate the wheels of the endoscope for tip steering. Experiments were conducted in an anatomical model to simulate gastroscopy. The image intensity- based algorithm was capable of steering the endoscope tip through an endoluminal path from the mouth to the duodenum accurately. Compared to manual control, the robotically steered endoscope performed 68% better in terms of keeping the lumen centered in the image

An Energy-Based State Observer for Dynamical Subsystems with Inaccessible State Variables

This work presents an energy-based state estimation formalism for a class of dynamical systems with inaccessible/ unknown outputs, and systems at which sensor utilization is impractical, or when measurements can not be taken. The power-conserving physical interconnections among most of the dynamical subsystems allow for power exchange through their power ports. Power exchange is conceptually considered as information exchange among the dynamical subsystems and further utilized to develop a natural feedback-like information from a class of dynamical systems with inaccessible/unknown outputs. This information is used in the design of an energybased state observer. Convergence stability of the estimation error for the proposed state observer is proved for systems with linear dynamics. Furthermore, robustness of the convergence stability is analyzed over a range of parameter deviation and model uncertainties. Experiments are conducted on a dynamical system with a single input and multiple inaccessible outputs (Fig. 1) to demonstrate the validity of the proposed energybased state estimation formalism

A Robust controller for micro-sized agents: The prescribed performance approach

Applications such as micromanipulation and minimally invasive surgery can be performed using micro-sized agents. For instance, drug-loaded magnetic micro-/nano- particles can enable targeted drug delivery. Their precise manipulation can be assured using a robust motion controller. In this paper, we design a closed-loop controller-observer pair for regulating the position of microagents. The prescribed performance technique is applied to control the microagents to follow desired motion trajectories. The position of the microagents are obtained using microscopic images and image processing. The velocities of the microagents are obtained using an iterative learning observer. The algorithm is tested experimentally on spherical magnetic microparticles that have an average diameter of 100 m. The steady-state errors obtained by the algorithm are 20 m. The errors converge to the steady-state in approximately 8 second

An energy-based state observer for dynamical subsystems with inaccessible state variables

This work presents an energy-based state estimation formalism for a class of dynamical systems with inaccessible/ unknown outputs, and systems at which sensor utilization is impractical, or when measurements can not be taken. The power-conserving physical interconnections among most of the dynamical subsystems allow for power exchange through their power ports. Power exchange is conceptually considered as information exchange among the dynamical subsystems and further utilized to develop a natural feedback-like information from a class of dynamical systems with inaccessible/unknown outputs. This information is used in the design of an energybased state observer. Convergence stability of the estimation error for the proposed state observer is proved for systems with linear dynamics. Furthermore, robustness of the convergence stability is analyzed over a range of parameter deviation and model uncertainties. Experiments are conducted on a dynamical system with a single input and multiple inaccessible outputs (Fig. 1) to demonstrate the validity of the proposed energybased state estimation formalism

Quantifying perception of nonlinear elastic tissue models using multidimensional scaling

Simplified soft tissue models used in surgical simulations cannot perfectly reproduce all material behaviors. In particular, many tissues exhibit the Poynting effect, which results in normal forces during shearing of tissue and is only observed in nonlinear elastic material models. In order to investigate and quantify the role of the Poynting effect on material discrimination, we performed a multidimensional scaling (MDS) study. Participants were presented with several pairs of shear and normal forces generated by a haptic device during interaction with virtual soft objects. Participants were asked to rate the similarity between the forces felt. The selection of the material parameters – and thus the magnitude of the shear\ud and normal forces – was based on a pre-study prior to the MDS experiment. It was observed that for nonlinear elastic tissue models exhibiting the Poynting effect, MDS analysis indicated that both shear and normal forces affect user perception